ASGR1 and cholelithiasis: Second, we investigated genetically mimicked effects of ASGR1 inhibitors on 25 traits selected a priori as known (lipid traits and CAD) [2, 3] or suspected (liver function and cholelithiasis) [5, 6] effects of inhibiting ASGR1, as well as adiposity and type 2 diabetes because these are well-known effects of statins [9] and have been suggested as general consequences of lowering LDL-cholesterol [10, 11].