Univariate analysis revealed that high BMI (> 23 kg/m2), high HOMA-IR (≥ 2.5), hypertension, high CRP (> 2 mg/L), the PNPLA3 rs738409 C > G variant, liver steatosis, high CAP, high TGs (≥ 1.7 mmol/L), high TC, and high LDL-C increased the risk for CKD, and the TM6SF2 rs58542926 C > T variant reduced the risk for CKD (all P < 0.05). The gene discussed is CRP; the disease is chronic kidney disease.