This study further confirmed that compared to those with PNPLA3 rs738409 CC, individuals with PNPLA3 rs738409 C > G had an increased risk of CKD, a lower eGFR, and were more likely to have advanced CKD G4–5; compared to those with TM6SF2 rs58542926 CC, individuals with TM6SF2 rs58542926 C > T had a decreased risk of CKD, a higher eGFR, and were less likely to have CKD G4–5. This evidence concerns the gene PNPLA3 and chronic kidney disease.