TM6SF2 and Insulin resistance: Moreover, patients in the CKD group with the PNPLA3 rs738409 non-CC genotype had a higher TG level and increased insulin resistance, a higher prevalence of CKD G4–5, and lower eGFR, and those with the TM6SF2 rs58542926 CC genotype had greater metabolic abnormalities, a higher prevalence of CKD G4–5, and a lower eGFR.