Multivariate analysis confirmed that besides hypertension, high BMI, high HOMA-IR, and high serum TGs, liver steatosis and the PNPLA3 rs738409 C > G variant remained associated with an increased risk of CKD, and the TM6SF2 rs58542926 C > T variant remained associated with a decreased risk of CKD (all P < 0.05). This evidence concerns the gene PNPLA3 and chronic kidney disease.