CD79A and IgA glomerulonephritis: Zheng et al. performed scRNA-seq of the kidney and CD14+ peripheral blood mononuclear cells (PBMC) collected from IgAN patients and healthy donors to compare the molecular differences between normal and IgAN mesangial cells and identified JCHAIN was one of the most significantly upregulated genes in IgAN mesangial cells, which was available to identify and transport IgA and deposit IgA in the glomerular mesangial, leading to IgA nephropathy.