Rudman-Melnick et al. performed scRNA-seq with the clinicall relevant unilateral ischemia-reperfusion model in mice at multiple AKI stages and found elevated expression of crucial injury response factors including kidney injury molecule-1 (Kim1), lipocalin 2 (Lcn2), and keratin 8 (Krt8)—and several novel genes (Ahnak, Sh3bgrl3, and Col18a1) not previously examined in kidney pathologies (Rudman-Melnick et al. 2020). The gene discussed is KRT8; the disease is acute kidney injury.