Another study found that M2 macrophages-derived EVs carried miR-21-5p entered into CD8 T cells to inhibit YOD1 expression and activate YAP/β-catenin pathway, thus promoting CD8 T cell depletion in hepatocellular carcinoma, which provided new insights into hepatocellular carcinoma immunotherapy [59]. This evidence concerns the gene CD8A and hepatocellular carcinoma.