Based on the ceRNA networks, we found that the hypoxic microenvironment may worsen the progression of NSCLC by regulating the NDRG1-009-miR-34c-5p-VEGFA, NDRG1-006-miR-346-EGLN3, NDRG1-009-miR-205-5p-VEGFA, and Hippo/HIF-1 signaling pathways. The gene discussed is EGLN3; the disease is non-small cell lung carcinoma.