These reports combined with our results suggest that a hypoxic microenvironment may worsen the progression of NSCLC by regulating the NDRG1-009-miR-34c-5p-VEGFA, NDRG1-006-miR-346-EGLN3, NDRG1-009-miR-205-5p-VEGFA, and Hippo/HIF-1 signaling pathways. This evidence concerns the gene HIF1A and non-small cell lung carcinoma.