NFKB1 and hepatocellular carcinoma: A previous study found that hepatocellular carcinoma (HCC) cell-associated EVs could be actively internalized by adipocytes, resulting in significant transcriptome changes; particularly, it was found that the induction of inflammatory phenotypes in adipocytes in addition to HCC cell-associated EVs could facilitate tumor growth, enhance angiogenesis, and recruit more macrophages by activating NF-κB pathway [19].