A previous study showed that miR-186-5p was abundant in M2 macrophage-derived EVs, and M2 macrophages-derived EVs delivered miR-186-5p to cells by targeting DLC1 expression, thereby enhancing the growth and motility of colon cancer cells by activating the β-catenin pathway [58]. The gene discussed is DLC1; the disease is malignant colon neoplasm.