However, the study of tear cytokine analysis for patients with acute SJS/TEN is lacking, except for one case report that monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and interleukin-8 (IL-8) were rapidly increased in an SJS patient’s tears at the acute stage [15]. This evidence concerns the gene CXCL8 and toxic epidermal necrolysis.