NLRP3 and gout: NLRP3 inflammasome mediates the development of many inflammatory diseases, like NASH, acute lung injury, gout, type 2 diabetes, and preeclampsia (Guan et al. 2022; Mangan et al. 2018; Szabo and Petrasek 2015; Zhao et al. 2021; Zhu and Liu 2022).