However, tumor stage (P = 0.016), tumor size (P = 0.028), vascular invasion (P = 0.035), lymph node metastasis (P = 0.016), BRAF V600E (P = 0.035) and NRAS Codon 12/13 (P = 0.021) were significantly different between the two groups. The gene discussed is BRAF; the disease is neoplasm.