While in vitro tumour lysis of PD-L1+ tumour cells was not improved by the addition of an IFP to the CAR T cells, their cytokine secretion in terms of IFN-γ (Fig. 2d), IL-2 (Supplementary Fig. 2C) and Granzyme B (Supplementary Fig. 2D) concentration in the coculture supernatant was higher than control T cells that were transduced with CAR only. This evidence concerns the gene IFNG and neoplasm.