Among the 381 HBV-targeted genes, 35 (AOAH, ANKS1B, CAMTA1, CDH4, CYP2E1, DSCAML1, EXOC4, FCHSD2, FSTL4, HIVEP3, HSPA12A, IGH, IQSEC1, JARID2, KCNQ3, LMF1, MED26, MLPH, MPG, NFAT5, NCOR2, PLD5, PTPRG, PTPRM, TRAPPC9, SLC29A3, SDCCAG8, SMOC1, SYNGR1, TGFBRAP1, WDR66, WNK2, ZHX2, ZMIZ1, ZNF536) were recurrently affected (in 2 or more samples) in tumour tissues and 1 (NRG3) in non-tumour tissues. This evidence concerns the gene IQSEC1 and neoplasm.