To further demonstrate the altered microbiota contributed to the enhanced IL-1β secretion, we sorted the LP CD11B+CD11C- monocytes, CD11B-CD11C+ dendritic cells, and CD11B+CD11C+ dendritic cells from WT mice and stimulated with fecal contents isolated from mock or tumor-bearing mice, respectively (Supplementary Fig. 2). This evidence concerns the gene IL1B and neoplasm.