PBRM1 and nonpapillary renal cell carcinoma: The driver gene analyses revealed that most driver genes in ccRCC encompassed variations in the chromosome 3p region: PBRM1 (94.4%), VHL (93.1%), SETD2 (90.3%), and BAP1 (87.5%) together with events in tumor suppressor genes on other chromosomes, such as CDKN2A/B (66.7%) and PTEN (30.6%) (Fig. 3, Supplementary data file).