KDM5C and hepatocellular carcinoma: While this manuscript was being prepared, a study reported that PRMT5/KDM5C-mediated dimethylation of ULK1 at R170 activates ULK1 to induce autophagy in LN229 glioblastoma (GBM) cells, Huh7 hepatocellular carcinoma (HCC) cells, and human oral keratinocytes (HOKs) in hypoxic environment, but not in normoxic condition[76].