PCK1 and metabolic dysfunction-associated steatohepatitis: Comparison to iPSC-Heps generated from three healthy-donor iPSC lines43 showed increased triglycerides in the NASH iPSC-Heps but normal insulin sensitivity as evidenced by unaltered glucose output and PCK1 and SREBP1c gene expression after insulin bolus (Fig. 2h–j, Supplementary Fig. 4m).