This specificity can be accounted for by the differential transcriptional networks we identify to be engaged by YAP-regulatory elements in these two disease models, revealing a connection between MAPK and YAP at the genomic level in mesothelioma, and the rewiring of a network of uveal melanoma-specific master regulators at YREs in uveal melanoma. The gene discussed is YAP1; the disease is uveal melanoma.