FOSL1 and mesothelioma: In the JUN locus, we found one site upstream of its TSS (−361 Kb) highly enriched for H3K27ac and H3K4me1 histone enhancer marks and displaying mesothelioma-specific YAP occupancy, as well as binding by the AP-1 TFs FOSL1 and JUN itself (Fig. 5a).