Next, we designed a comprehensive CRISPR library containing approximately 160,000 sgRNAs targeting the most significant YAP-peak summits among the four cell lines (ntotal peaks = 18039, −Log10FDR > 49; 2941 peaks common to both lineages, 6389 mesothelioma-specific peaks, 2119 uveal melanoma-specific peaks, 2938 cell line-specific peaks and 3652 peaks in other distributions) (Fig. S2A–, C and Supplementary Data 1). The gene discussed is YAP1; the disease is uveal melanoma.