Blocking GPL metabolism in cancer cells has become a potential treatment for colorectal cancer.[32, 33, 34, 35] In this study, GLP metabolic pathway inhibitor D609 was selected for its effect on the proliferation of two colorectal cancer cell lines (HCT116 and SW620), and the results showed that D609 significantly the reduced the level of PC and PE (Figure 7I–L), inhibited the proliferation of CRC cell lines (Figure 7M,N). This evidence concerns the gene IL31RA and colorectal cancer.