Meanwhile, male mice also presented more and bigger tumors (Figure 1C), larger proportion of adenocarcinoma and high‐grade and low‐grade dysplasia (Figure 1D), more Ki‐67 positive cells (Figure 1E), and less goblet cells (Figure 1F) than females, indicating that the sexual dimorphism in CRC was more obvious for ApcMin/+ mice with high‐fat diet. Here, MKI67 is linked to adenocarcinoma.