PLA2G1B and colorectal carcinoma: LPC is the downstream metabolite of PC, and the pro‐tumorigenic function of PC has been reported.[59] LPA and LPC are both bioactive lipolytic products of phospholipase A2 group 1B (PLA2g1b) which could be modulated by gut microbiota.[60, 61] In addition, increasing evidence supports that LPC can promote colorectal tumorigenesis,[62, 63] which is in accordance with our results that LPC promoted the proliferation of CRC cells and accelerated their cell cycle.