IL31RA and colorectal cancer: Activation of glycerophospholipid metabolism pathway accelerates the progression of colorectal cancer.[29, 30, 31] Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were abnormally accumulated in patients with colorectal cancer.[30] To investigate the role of GPL in CRC development, we measured the levels of PC and PE in the colon tissues of ApcMin/+ mice.