After NMA was loaded into hyaluronic acid (HA)‐modified hollow MnO2 nanoparticles (hMnO2 NPs), the obtained hMnO2@HA@NMA (MHN) nanogenerators (NGs) were able to accumulate at tumor sites through CD44 active targeting, and release Mn2+ ions in the tumor microenvironment (TME). Here, CD44 is linked to neoplasm.