Our previous work utilized hollow MnO2 nanozymes as carriers to deliver budesonide for synergistic inflammatory bowel disease therapy.[22] The process of catalyzing H2O2 can simultaneously release Mn2+, contributing to cyclic GMP‐AMP (cGAMP) formation caused by pyroptosis‐induced double‐stranded DNA (dsDNA) release for subsequent tumor cGAS‐STING (cyclic GMP‐AMP synthase‐stimulator of interferon genes) immunotherapy.[23]. Here, STING1 is linked to neoplasm.