A 16–18% T2D risk reduction was observed for ACE inhibitors (T2D OR = 0.82, 95% CI = 0.78, 0.86, p = 3.3 x 10−17 [IVW MR association]) and minoxidil/verapamil (T2D OR = 0.84, 95% CI = 0.81, 0.87, p = 5.0 x 10−25 [IVW MR association]) via changes in predicted systolic blood pressure. The gene discussed is ACE; the disease is type 2 diabetes mellitus.