TTR and AL amyloidosis: PET markers identify both ATTR and AL amyloidosis and are either scored visually or by determining quantitative parameters such as the tracer retention index or the myocardium-blood standardized uptake ratio value.21 PET and DPD scintigraphy in SPECT technique target directly amyloid deposition in the tissue and thus allow a degree of quantitation of cardiac amyloid, suggesting the possibility to monitor therapy by imaging, with confirmatory data emerging22 (Figure 4).