Oncogenic splicing switches driven by hnRNP H include targets such as IG20/MADD in glioma (32), TCF3 in lymphoma (35), HER2 and Mcl-1 in breast cancer (36, 37), KHK in hepatocellular carcinoma (38), and A-Raf in colon and head and neck cancers (33). Here, MADD is linked to central nervous system cancer.