In contrast, assessment of avidity accounts for the collective interactions of multiple receptor/ligand complexes and co-receptors which make up the immunological synapse between cells and can thus lead to more accurate predictions of T-cell functionality.23 We confirmed deficient target binding by APRIL CAR and reduced avidity between APRIL CAR expressing cells and the human myeloma cell line H929 compared with bb2121 and LCAR-B38M. This evidence concerns the gene AQP1 and plasma cell myeloma.