In a preclinical study, we observed the cytotoxicity of APRIL CAR T-cells against cell lines expressing physiological levels of BCMA and TACI as well as primary tumor cells, maintained target kill in the presence of soluble BCMA, TACI or APRIL, and finally, rapid clearance of tumor in an in vivo myeloma model.5 This evidence concerns the gene TNFRSF13B and neoplasm.