F2 and varicose disease: The mean value of Prothrombin time was (28.21 + 11.5) sec in the group with varices as compared to the group without varices (21.04 +7.0) sec but was marginally insignificant (p value-0.051) although on comparing serum prothrombin time values between patients with Large varices (Grade III/IV) (Group A) with a mean value of 31.63± 13.2 sec vs. Grade I/II/No varices (Group B) with a mean value of 25.21±8.9 sec, which was significantly higher in Group A patients (<0.009) (Tables 6, 7 and Figures 6, 7).