Firstly, although we have analyzed the expression of six MRGs using both clinical samples and datasets, and confirmed the changes in mitochondrial function through in vitro sepsis models, additional investigations are required to substantiate the roles of PID1, CS, CYP1B1, FLVCR1, IFIT2, or MAPK14 in the course of sepsis. This evidence concerns the gene IFIT2 and Sepsis.