Use of CD11c-Hhex transgenic mice revealed that high levels of Hhex during myeloid development may induce myeloid leukaemia, with higher cell cycle rates observed, although leukemogenesis was slow (18 months of age), implying that further mutation(s) were required in addition to Hhex overexpression (91). This evidence concerns the gene HHEX and myeloid leukemia.