HHEX and type 2 diabetes mellitus: A number of allelic SNPs (rs1111875, rs5015480 and rs7923837) within the Hhex gene have been implicated to varying degrees as T2D risk factors, with a Genome-Wide Association Study (GWAS) linking rs5015480 with gestational diabetes mellitus with these studies and meta-analyses showing that the ethnic background of the patient population is the most important factor as to whether a Hhex SNP risk factor allele applies and to what extent (Supplementary Table 1) (142).