RUNX1 and myeloid leukemia: Hhex expression, in combination with a mutant form of additional sex combs-like 1 (Asxl1) an epigenetic modulator often mutated in myeloid leukaemia, was also found to enhance Runx1-ETO and Flt3-ITD-driven myeloid leukaemia via upregulation of Myb and Etv5 in mice (119).