The clearest evidence for this was shown in a murine model Lmo2-induced leukaemia in mice and T-ALL patient samples, where it was revealed upregulation of Hhex as an integral part of a broader induction of an HSC transcriptional programme and where Hhex could additionally phenocopy the action of Lmo2 in early leukaemogenesis (Figure 3) (104). Here, LMO2 is linked to acute lymphoblastic leukemia.