The clearest evidence for this was shown in a murine model Lmo2-induced leukaemia in mice and T-ALL patient samples, where it was revealed upregulation of Hhex as an integral part of a broader induction of an HSC transcriptional programme and where Hhex could additionally phenocopy the action of Lmo2 in early leukaemogenesis (Figure 3) (104). Here, HHEX is linked to leukemia.