Ldb1 and Lmo2 were also reported to bind the promoters of Hhex, Lyl1 and Nfe2, resulting in their upregulation in HSPCs and human ETP-ALL cell lines, as well as pre-leukaemic Lmo2 transgenic thymocytes in the murine Lmo2-induced T-ALL model (109). Here, HHEX is linked to acute lymphoblastic leukemia.