Whilst another group subsequently examined the thyroid tissue of Chinese children suffering from TD for Hhex mutations (162), they also failed to show any link between Hhex mutations and TD, along with FOXE1, TTF-1 and PAX8, but still observed a correlation with the intronic mutation rs2275729, although owing largely to the small study size, further work is required to determine its potential importance (162). Here, HHEX is linked to thanatophoric dysplasia.