Despite Hhex containing a PML-interaction domain (Figure 1), it did not require PML for transformation, nor did it require p16INK4a and p19Arf indicating Hhex did not require PRC2-mediated epigenetic repression for this particular process unlike what we observed for the induction of AML (120). This evidence concerns the gene CDKN2A and acute myeloid leukemia.