A novel subset of γδ T cells that express both gut-homing integrins CD103 (αE) and α4β7 (CD103+ and α4β7high) has been identified in gut-draining MLNs and in intestinal epithelial and lamina propria compartments of mice with T cell-mediated colitis and spontaneous chronic intestinal inflammation (48). Here, ITGAE is linked to gastroenteritis.