Tox DKO (TOX1, TOX2) CAR-T cells1. ACT (transfer of Tox DKO CAR-T cells into tumor models);2. Limited tumor growth;3. Promoted cytokine production (TNF, IFN-γ);4. Downregulated the expression of inhibitory receptors (PD-1, TIM3 and LAG3);. Here, TNF is linked to neoplasm.