GZMB and neoplasm: IRF2-deficient CD8+ T cells (CD8-irf2 cKO mice)1. ACT (transfer of IRF2-deficient CD8+ T cells into tumor model);2. Slowed down tumor growth;3. Low expression of inhibitory receptors and the enhanced production of Granzyme B, perforin and IFN-γ;4. No expression of TOX;