PGC1αOE (CAR-T cells overexpressing PGC1α)1. ACT (transfer of CAR-T cells overexpressing PGC1α into tumor model);2. Limited tumor growth;3. PGC1αOE without progenitor exhausted signature;4. Altered differentiation and avoided the differentiation of TEXs;. The gene discussed is PPARGC1A; the disease is neoplasm.