Expressions of MAGE-A (27, 103), MAGE-3, NY-ESO-1 (104), beta-2-microglobulin, calreticulin, CD58, proteasome 20S subunit beta 8 (PSMB8), and PSMB9 (105) were increased significantly in esophageal cancer and CRC after the treatment of decitabine. The gene discussed is MAGEA3; the disease is esophageal cancer.