By conducting SMR and HEIDI methods, several non-MHC region SNPs were identified as common shared genetic loci including rs143334143 (TCF19), rs2277732 (DPP9), rs77534576 (DLX3), and rs13081151 (FLT1P1), among others, which were significantly associated with OA-critical COVID-19 combined trait. The gene discussed is FLT1P1; the disease is COVID-19.