If these or other future studies are successful in reversing the LH/FSH ratio and reinitiating follicular development, findings could be applied for potential benefits in insulin resistance, endometrial hyperplasia, hair growth, acne, etc. We are not certain that insulin resistance would be alleviated if our hypothesis had been met, but it is possible that normalization of the steroid milieu over a long period could affect insulin sensitivity and potentially impact BMI. The gene discussed is PLOD1; the disease is acne.