Interestingly, T98G cells expressing high level of O6-methylguanine DNA-methyltransferase (MGMT), the main regulator of TMZ resistance in glioblastomas also showed increase in miR-10b expression after incubation with TMZ similar to all other cell lines tested and its decrease after treatment with MN-anti-miR10b (Supplementary Figure S6A). The gene discussed is MGMT; the disease is glioblastoma.