Exercise-induced benefits on MDD are most commonly associated with certain neuro-molecular mechanisms including; increasing the levels of serotonin and norepinephrine (Ross et al., 2023), increasing the expression of neurotrophins such as brain-derived neurotrophic factor (Russo-Neustadt et al., 2000), regulating the hypothalamic-pituitary-adrenal (HPA) axis activity (Lopresti et al., 2013), as well as reducing inflammation (Paolucci et al., 2018). Here, BDNF is linked to major depressive disorder.