At the CFI locus, SMR detected SNP rs7439493 influencing PLA2G12A expression and AMD risk (SMR P-value = 2.6×10−8 and HEIDI P-value = 0.22) (Extended Data Fig. 6a), as identified in our previous eQTL study29. This evidence concerns the gene PLA2G12A and age-related macular degeneration.