SNP rs67538026 associated with methylation of CpG cg05475770, TMEM259 expression and AMD risk was identified at the CNN2 locus (Fig. 5d), and rs114820183 associated with cg22670819 methylation, DXO expression, and AMD risk at the C2-CFB-SKIV2L locus. The gene discussed is CNN2; the disease is age-related macular degeneration.