At the AMD locus rs147859257/rs2230199 on chromosome 19, both a mQTL (cg12024887 and cg07567260 that mapped to GRP108, MIR6791 and TRIP10) and an eQTL (acting on GRP108) colocalized with the AMD association signal, suggesting that the causal effect of the colocalizing mQTL in this AMD locus may be acting via altered GRP108 expression levels (Extended Data Fig. 6e, 6f and 6g). The gene discussed is TRIP10; the disease is age-related macular degeneration.