The retina mQTLs and eQTLs proposed the same target genes for one locus PILRB/PILRA, and new causal mechanisms and genes for AMD at 3 (KMT2E/SRPK2, PILRB/PILRA and ARMS2/HTRA1) and 2 (C2/CFB/SKIV2L and PILRB/PILRA) loci, respectively. The gene discussed is PILRB; the disease is age-related macular degeneration.