A subset of FS symptoms, such as dystonia, myoclonus, and ataxia, may be attributed to the downregulation of PLEKHG2, DST, ARX, AAAS, KCTD17, PRDM8, and CRTC1 in FS brains as these genes are downregulated in Q84Pfs-Het brains and play a role in these movement and muscle coordination 43–49. Here, CRTC1 is linked to cerebellar ataxia.