Fmr1, Nalcn, Il1rapl1, and Slc16a2, which are aberrantly upregulated in Q84Pfs-Het brains, are likely to be involved in intellectual disability, social impairment, and autism-like behaviors, given that these genes are associated with neurodevelopmental disorders with the described signature behaviors 39–42. Here, NALCN is linked to Intellectual disability.