MAPT and Alzheimer disease: Sections were stained with a panel of 38 metal-tagged antibodies (Extended Data Table S1) capturing neuronal structures including soma, dendrites, axons, synapses, astrocytes, myelin, vasculature, cellular processes including metabolism, proteolysis and translation, the hallmark AD neuropathologic changes (ADNC) including amyloid-β (Aβ) plaques and tau tangles, and a sub panel of 17 microglial phenotyping proteins.