We also noticed that, while integrin b1 expression is full restored in USP22-null mouse and human breast cancer cells, FoxM1 expression only achieved a partial rescue in their in vitro tumor sphere formation and in vivo lung metastasis, indicating that USP22 exerts it cancer stem cell gene function in part through an integrin b1-indepent manner. The gene discussed is FOXM1; the disease is breast cancer.