Cases with NPM1 fusions or indels outside the N-terminus48 clustered with canonical NPM1 mutations, and thus we assigned them to the NPM1 category (Fig.S4A), and similarly, TBL1XR1::RARB49 to the APL (acute promyelocytic leukemia) category. This evidence concerns the gene TBL1XR1 and acute promyelocytic leukemia.