In human subcutaneous WAT, DNM1L (encoding human Drp1 protein) expression was positively correlated with BMI and HOMA (Fig. 5f,g), and its expression was significantly upregulated in obese subjects (Fig. 5h), indicating that increased expression of DNM1L may contribute to mitochondrial dysfunction in obesity. The gene discussed is DNM1L; the disease is obesity due to melanocortin 4 receptor deficiency.