A salient finding in the present study is the peripheral blood monocyte gene co-expression related to inflammatory processes in high-SI participants, with enrichment of genes in Pyroptosis Signaling, TREM1 Signaling, NF-κB signaling, T Cell Receptor Signaling, Systemic Lupus Erythematosus In B Cell Signaling, Calcium-induced T Lymphocyte Apoptosis, and trend wise enrichment of genes in neuroinflammation pathways in the high SI vs. no SI groups. Here, NFKB1 is linked to systemic lupus erythematosus.