The genes <i>NMNAT2</i>, <i>ZFP42</i>, <i>NPAS2</i>, <i>MYLK3</i>, <i>NUDT13</i>, <i>KIRREL3</i>, and <i>FKBP6</i> and hub genes <i>SOST</i>, <i>NFATC1</i>, and <i>TLE4</i> were associated with survival time in the most aggressive form of the disease that can serve as potential diagnostic targets for early CRC detection. The gene discussed is TLE4; the disease is colorectal carcinoma.