AKT1 and pachyonychia congenita: The etiology of the tumor remains unclear, but molecular analysis studies recognize several genes that play a central role in the molecular pathogenesis of PC, such as HRPT2 gene,5, 6 germ‐line missense variants of the parathyroid transcription factor gene GCM27, 8 and the somatic alteration of PI3K/AKT/MTOR pathway.9, 10