Interleukin‐1, IL‐6, IL‐18, interferon‐gamma, and TNF‐α play a key role in the pathogenesis of AOSD, and elevated IL‐1 and IL‐18 levels are closely associated with the systemic symptoms of AOSD, such as fever, rash, and liver dysfunction.18 The gene discussed is TNF; the disease is Decreased liver function.