Interleukin‐1, IL‐6, IL‐18, interferon‐gamma, and TNF‐α play a key role in the pathogenesis of AOSD, and elevated IL‐1 and IL‐18 levels are closely associated with the systemic symptoms of AOSD, such as fever, rash, and liver dysfunction.18 The gene discussed is IL6; the disease is adult-onset Still disease.