These cells can turn the microenvironment in their favor, deceive the immune system of the body, and can exploit the physiology of other cells to accommodate their needs.1, 2, 3, 4, 5, 6 Some of the biomarkers which are currently been used to detect cancer including human epididymis protein 4 (HE4), carcinoembryonic antigen (CEA), legumain, mesothelin, osteopontin, and vitamin E-binding plasma protein. The gene discussed is CEACAM5; the disease is cancer.