MUTYH and mutyh-associated polyposis: Moreover, homozygous MUTYH c.536A>G pathogenic variants are associated with a more severe MAP clinical course than other homozygous MUTYH mutations and a higher risk of developing CRC than homozygous c.1187G>A or compound heterozygous c.536A>G/c.1187G>A MUTYH variants.2