Indeed, the median age of diagnosis of colorectal polypoid lesions and/or CRC was 50 years (range 36–63) for the APC c.1111G>T pathogenic variant and 61 years (range 40–79) for the MUTYH c.536A>G pathogenic variant, while an earlier disease diagnosis (42.5 years, range 42–43) trend was observed in patients carrying both (Table 1B). This evidence concerns the gene MUTYH and colorectal carcinoma.