A polyphenolic flavonoid, Glabridin exhibits anti-tumour activity in breast cancer cell lines by inducing paraptosis in many human malignancies by elevating the expression of different ER stress markers like Bip, XBPIs, CHOP and by inducing ROS production and mitochondrial dysfunction (Cui and Cui, 2022). This evidence concerns the gene DDIT3 and breast carcinoma.