An increase in the intracellular Cl− concentration by the activation of chloride intracellular channel-1 (CLIC1) induced paraptosis by a purified resin glycoside fraction (RFP) of Pharbitidis Semen in human colon cancer cell line, thus suggesting CLIC1 as another channel playing a role in paraptosis (Zhu et al., 2019). Here, CLIC1 is linked to malignant colon neoplasm.