SLC4A4 and cancer: Recently, it has been demonstrated that the SLC4A4 inhibition mitigated the acidosis of the TME in PAAD due to bicarbonate accumulation in the extracellular space and the reduction of the lactate secretion by cancer cells, which affected the T cell-mediated immune response and macrophage-mediated immunosuppression (Cappellesso et al., 2022).