Despite the role of riboflavin in human health and cancer has been widely investigated in the last decades (Thakur et al., 2017), the involvement of its main transponder in tumorigenesis has been poorly investigated, except for few studies that focused on colorectal cancer and esophageal squamous cell carcinoma reporting SLC52A3 up- and downregulation, respectively (Ainiwaer et al., 2013; Tutino et al., 2018; Li et al., 2022). This evidence concerns the gene SLC52A3 and colorectal cancer.