MLKL and neoplasm: The H&E-stained sections of EBI-treated groups displayed markedly enhanced tumor necrosis compared to the control group (Figure 7A), and the phosphorylation level of MLKL in necrotic areas of EBI-treated tumors elevated substantially in a dose-dependent manner, while only modest amount of MLKL phosphorylation was detected in the control group (Figure 7A).