In particular, mast cells contribute to asthma airway inflammatory processes through immunoglobulin (Ig) E-dependent or non-IgE-dependent mechanisms (Galli, and Costa, 1995; Galli, 1997; Galli and Tsai, 2012; Bradding and Saito, 2019; Galli et al., 2020). Here, IGHE is linked to asthma.