However, serum FLC concentrations seem to be independent of atopy, as their values were normal in mild asthma adults, were similar in atopic or nonatopic severe asthma individuals, were similar in severe asthma individuals irrespective of serum total IgE (≥100 kU/L), and were not correlated with total serum IgE or serum specific IgE. The gene discussed is IGHE; the disease is asthma.