Severe asthma adults with peripheral blood eosinophil cell counts > 300 cells/μL showed higher serum κ (p < 0.001) and λ FLC concentrations (p < 0.01) than severe asthma adults with peripheral blood eosinophil cell counts ≤ 300 cells/μL (Table 3; Figure 3A), whereas serum κ and λ FLC concentrations were similar across study groups with high or low serum total IgE (Table 3; Figure 3B), with or without atopy as measured by serum specific IgE (Table 3; Figure 3C), or high or low FENO concentrations (Table 3; Figure 3D). Here, IGHE is linked to asthma.