PLAT and intracerebral hemorrhage: Although tPA can promote cerebral reperfusion it also increases the risk of intracerebral hemorrhage (Gravanis and Tsirka, 2008; Vivien, 2017; Boese et al., 2020) and may negatively affect neuronal viability (Wang et al., 1998) and exert direct neurotoxic effects (Vivien, 2017; Zhu et al., 2019; Yepes et al., 2021).