The above researches showed that acupuncture at CV17, CV12, CV6, ST36, SP10, GV24, GV20, KI3, BL17, and SP6 can regulate the state of immune cells, inhibit the activation of inflammatory pathways (TLR/MyD88/NF-κB, ERK, Sirt1/STAT3), and inhibit the release of inflammatory factors (IL-1β, IL-2, IL-6, TNF-α, INF-γ, MIP-2, COX-2, and iNOS), and improve cognitive impairment after stroke. Here, STAT3 is linked to Stroke.