Studies have shown that stroke can inhibit the expression of proteins that maintain synaptic structures (presynaptic and postsynaptic membrane scaffold proteins such as synaptophysin-1, synaptophysin and PSD-95) and proteins that regulate the integrity of synaptic functions (such as brain derived nutritional factor, microtubule associated protein-2, calcium/calmodulin dependent protein kinase 2, etc.)(Chi et al., 2023). The gene discussed is CAMKK2; the disease is Stroke.