CD4 and Cognitive impairment: MA at the above acupoints can also reduce the frequency and quantity of Th17 cells in these animals, increase Treg cell levels, regulate Th17/Treg balance, reduce CD4+RORγT+ and RORγT+ cells, increase CD4+FoxP3+ and FoxP3+ cell counts, thereby alleviating cognitive deficits in spatial learning and memory disorders (Qiuping et al., 2023).