MA at ST36 and GV20 can also upregulate the expression of Trx-1 and TrxR-1, increase TrxR-1 activity, inhibit the activation of downstream ASK1-JNK/p38 pathway, inhibit oxidative stress and neuronal apoptosis damage in the hippocampus, and improve cognitive impairment caused by cerebral ischemia injury (Zhu et al., 2018). This evidence concerns the gene MAPK8 and Cognitive impairment.