TP53 and Cognitive impairment: EA can also upregulate the protein and mRNA expressions of Bcl-2, inhibit activator protein (AP)-1, p53, and Bax, alleviate the apoptosis of hippocampal cells in rats induced by modified bilateral common carotid artery occlusion (BCCAO), and improve their cognitive impairment, which may be related to the inhibition of JNK signaling pathway (Liu et al., 2022).