ADRB1 and Cognitive impairment: Meanwhile, this study found that inhibition β-adrenergic receptor (AR) instead of α-AR can block the effect of acupuncture on LTP in the hippocampus, and inhibition of β1-AR, not β2-AR, abolished the enhanced LTP, indicating the increase of NE in the hippocampus and the activation of β1-AR is a possible mechanism mediating acupuncture to improve cognitive impairment in PSCI (Xiao et al., 2018).