EA at related Jing-well points, such as Shaochong (HT9), Zhongchong (PC9), Yongquan (KI1) and Shaoshang (LU11) can significantly reduce the level of NO and upregulate SOD activity in the midbrain tissue and serum, enhance the ability to clear free radicals in modified 4-vessel occlusion induced rats, further improve cognitive impairment (He, 2012). Here, SOD1 is linked to Cognitive impairment.