EA at Taixi (KI3) and GV20 can reduce the expression of neuroinflammatory proteins in the hippocampus of gerbils that had undergone BCCAO, including ionized calcium binding junction molecule 1, TLR4, TNF-α and phospho-extracellular signal-regulated kinase (pERK) to improve inflammatory response and cognitive impairment (Yang et al., 2016). This evidence concerns the gene TLR4 and Cognitive impairment.