The above researches showed that acupuncture at CV17, CV12, CV6, ST36, SP10, GV20 and GV24 can regulate the intracellular apoptotic pathway (JNK, NF-κB), increase the Bcl-2/Bax ratio, inhibit neuronal apoptosis, and improve cognitive impairment after stroke. The gene discussed is MAPK8; the disease is Cognitive impairment.