MAP3K5 and Cognitive impairment: MA at ST36 and GV20 can also upregulate the expression of Trx-1 and TrxR-1, increase TrxR-1 activity, inhibit the activation of downstream ASK1-JNK/p38 pathway, inhibit oxidative stress and neuronal apoptosis damage in the hippocampus, and improve cognitive impairment caused by cerebral ischemia injury (Zhu et al., 2018).