DICER1 and colitis: Fecal miRNA can: shape microbiota profile, as fecal miRNA from Dicer1 expressing mice shifted the microbiome diversity in Dicer1 KO mice to a higher similarity/lower diversity; and alter intestinal barrier function, as fecal miRNAs from Dicer1 expressing mice ameliorated weight loss and colon damage in Dicer1 KO animals in response to DSS-induced colitis.