In accordance with the findings that chronic stress increases the effect of vasopressin on ACTH secretion, we hypothesized: 1) Intranasal desmopressin would increase ACTH secretion in cocaine use disorder patients more than in a non-addicted control group; 2) Pre-treatment with intranasal oxytocin would blunt the ACTH secretion induced by intranasal desmopressin more so in the cocaine use disorder group than in a non-addicted control group. The gene discussed is POMC; the disease is cocaine use disorder.